KIF5C


Summary: The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kinesin family member 5CMIM:604593Ensembl:ENSG00000168280HGNC:HGNC:6325PA301092q23.1-q23.2

GO terms in KIF5C


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003777microtubule motor activity
MFTASGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008017microtubule binding
MFIEAGO:0008017microtubule binding
MFIBAGO:0008574ATP-dependent microtubule motor activity, plus-end-directed
MFIBAGO:0016887ATPase activity
CCIEAGO:0005737cytoplasm
CCIBAGO:0005871kinesin complex
CCTASGO:0005871kinesin complex
CCIBAGO:0005874microtubule
CCIEAGO:0005874microtubule
CCIEAGO:0030425dendrite
CCIEAGO:0035253ciliary rootlet
CCISSGO:0043025neuronal cell body
CCISSGO:0044295axonal growth cone
CCISSGO:0150034distal axon
BPTASGO:0006996organelle organization
BPIBAGO:0007018microtubule-based movement
BPIBAGO:0007411axon guidance
BPIEAGO:0008045motor neuron axon guidance
BPIBAGO:0030705cytoskeleton-dependent intracellular transport
BPIBAGO:0048489synaptic vesicle transport
BPISSGO:0051028mRNA transport
BPIBAGO:0098971anterograde dendritic transport of neurotransmitter receptor complex

Gene expression in normal tissue: KIF5C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIF5C


DatabasePathway IDPathway Des.
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
reactomeR-HSA-264876Insulin processing
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIF5C

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