KLC3
Summary: This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin light chain 3 | MIM:601334 | Ensembl:ENSG00000104892 | HGNC:HGNC:20717 | PA142671588 | 19q13.32 |
GO terms in KLC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0008088 | axo-dendritic transport |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005871 | kinesin complex |
| CC | IEA | GO:0005874 | microtubule |
| CC | IEA | GO:0031514 | motile cilium |
| CC | IEA | GO:0035253 | ciliary rootlet |
| CC | IEA | GO:0043005 | neuron projection |
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0019894 | kinesin binding |
Gene expression in normal tissue: KLC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-983189 | Kinesins |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLC3
CLASSFICATION
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