KRT5


Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
keratin 5MIM:148040Ensembl:ENSG00000186081HGNC:HGNC:6442PA3023012q13.13

GO terms in KRT5


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005882intermediate filament
CCIEAGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIDAGO:0045095keratin filament
CCHDAGO:0070062extracellular exosome
BPIEAGO:0007010cytoskeleton organization
BPTASGO:0008544epidermis development
BPTASGO:0031424keratinization
BPTASGO:0031581hemidesmosome assembly
BPTASGO:0070268cornification
MFTASGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
MFIPIGO:0097110scaffold protein binding

Gene expression in normal tissue: KRT5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRT5


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-446107Type I hemidesmosome assembly
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope
netpathPathway_EGFR1EGFR1
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidreg_gr_pathwayGlucocorticoid receptor regulatory network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD283Bosutinib1
iGMDRD503CMK1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRT5

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