LCN2
Summary: This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lipocalin 2 | MIM:600181 | Ensembl:ENSG00000148346 | HGNC:HGNC:6526 | PA30309 | 9q34.11 |
GO terms in LCN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0005506 | iron ion binding |
| MF | IEA | GO:0036094 | small molecule binding |
| CC | HDA | GO:0005576 | extracellular region |
| CC | ISS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0006811 | ion transport |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0015891 | siderophore transport |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | ISS | GO:0045087 | innate immune response |
Gene expression in normal tissue: LCN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LCN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6799990 | Metal sequestration by antimicrobial proteins |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
| reactome | R-HSA-917937 | Iron uptake and transport |
| reactome | R-HSA-917937 | Iron uptake and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LCN2
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