Summary: This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015].

lipocalin 2MIM:600181Ensembl:ENSG00000148346HGNC:HGNC:6526PA303099q34.11

GO terms in LCN2

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0005506iron ion binding
MFIEAGO:0036094small molecule binding
CCHDAGO:0005576extracellular region
CCISSGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0035580specific granule lumen
CCHDAGO:0070062extracellular exosome
BPIEAGO:0006811ion transport
BPTASGO:0006879cellular iron ion homeostasis
BPIEAGO:0006915apoptotic process
BPISSGO:0015891siderophore transport
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019730antimicrobial humoral response
BPTASGO:0043312neutrophil degranulation
BPISSGO:0045087innate immune response

Gene expression in normal tissue: LCN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LCN2

DatabasePathway IDPathway Des.
wikipathwaysWP4066Interleukin-4 and 13 signaling
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6799990Metal sequestration by antimicrobial proteins
reactomeR-HSA-6803157Antimicrobial peptides
reactomeR-HSA-917937Iron uptake and transport
reactomeR-HSA-917937Iron uptake and transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LCN2