LDB2
Summary: The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain binding 2 | MIM:603450 | Ensembl:ENSG00000169744 | HGNC:HGNC:6533 | PA30317 | 4p15.32 |
GO terms in LDB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IEA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IBA | GO:0030274 | LIM domain binding |
| MF | ISS | GO:0030274 | LIM domain binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0031252 | cell leading edge |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001942 | hair follicle development |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0010669 | epithelial structure maintenance |
| BP | ISS | GO:0030334 | regulation of cell migration |
| BP | IEA | GO:0035019 | somatic stem cell population maintenance |
| BP | ISS | GO:0043549 | regulation of kinase activity |
| BP | IEA | GO:0044089 | positive regulation of cellular component biogenesis |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: LDB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LDB2
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