Summary: The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

LIM domain binding 2MIM:603450Ensembl:ENSG00000169744HGNC:HGNC:6533PA303174p15.32

GO terms in LDB2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000989transcription factor activity, transcription factor binding
MFIEAGO:0000989transcription factor activity, transcription factor binding
MFIBAGO:0001102RNA polymerase II activating transcription factor binding
MFTASGO:0003712transcription coregulator activity
MFIPIGO:0005515protein binding
MFIEAGO:0019899enzyme binding
MFIBAGO:0030274LIM domain binding
MFISSGO:0030274LIM domain binding
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005667transcription factor complex
CCIDAGO:0005886plasma membrane
CCISSGO:0031252cell leading edge
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001942hair follicle development
BPIBAGO:0007275multicellular organism development
BPIEAGO:0010669epithelial structure maintenance
BPISSGO:0030334regulation of cell migration
BPIEAGO:0035019somatic stem cell population maintenance
BPISSGO:0043549regulation of kinase activity
BPIEAGO:0044089positive regulation of cellular component biogenesis
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: LDB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LDB2

DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LDB2