LGR6


Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
leucine rich repeat containing G protein-coupled receptor 6MIM:606653Ensembl:ENSG00000133067HGNC:HGNC:19719PA1349271141q32.1

GO terms in LGR6


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0016055Wnt signaling pathway
BPIDAGO:0030177positive regulation of Wnt signaling pathway
BPIDAGO:0030335positive regulation of cell migration
BPISSGO:0090263positive regulation of canonical Wnt signaling pathway
BPIEAGO:1990523bone regeneration
CCTASGO:0005886plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIDAGO:0031982vesicle
CCISSGO:0032588trans-Golgi network membrane
MFISSGO:0004888transmembrane signaling receptor activity
MFISSGO:0004930G-protein coupled receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0016500protein-hormone receptor activity

Gene expression in normal tissue: LGR6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LGR6


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-4641263Regulation of FZD by ubiquitination
wikipathwaysWP117GPCRs, Other

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LGR6

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