LIPH
Summary: This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lipase H | MIM:607365 | Ensembl:ENSG00000163898 | HGNC:HGNC:18483 | PA134934352 | 3q27.2 |
GO terms in LIPH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004620 | phospholipase activity |
| MF | TAS | GO:0004620 | phospholipase activity |
| MF | IDA | GO:0008201 | heparin binding |
| MF | IEA | GO:0052689 | carboxylic ester hydrolase activity |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | TAS | GO:0006654 | phosphatidic acid biosynthetic process |
| BP | IDA | GO:0016042 | lipid catabolic process |
Gene expression in normal tissue: LIPH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIPH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483166 | Synthesis of PA |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LIPH
CLASSFICATION
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