LIPH


Summary: This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lipase HMIM:607365Ensembl:ENSG00000163898HGNC:HGNC:18483PA1349343523q27.2

GO terms in LIPH


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004620phospholipase activity
MFTASGO:0004620phospholipase activity
MFIDAGO:0008201heparin binding
MFIEAGO:0052689carboxylic ester hydrolase activity
CCIDAGO:0005615extracellular space
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
BPTASGO:0006654phosphatidic acid biosynthetic process
BPIDAGO:0016042lipid catabolic process

Gene expression in normal tissue: LIPH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LIPH


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483166Synthesis of PA
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIPH

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