LPO


Summary: This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lactoperoxidaseMIM:150205Ensembl:ENSG00000167419HGNC:HGNC:6678PA3043917q22

Gene Categories:

DRUGGABLE GENOME

GO terms in LPO


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004601peroxidase activity
MFIEAGO:0020037heme binding
MFIBAGO:0036393thiocyanate peroxidase activity
MFIDAGO:0036393thiocyanate peroxidase activity
MFIEAGO:0046872metal ion binding
BPIDAGO:0001580detection of chemical stimulus involved in sensory perception of bitter taste
BPNASGO:0006979response to oxidative stress
BPIEAGO:0018969thiocyanate metabolic process
BPIBAGO:0042742defense response to bacterium
BPIDAGO:0042742defense response to bacterium
BPIEAGO:0042744hydrogen peroxide catabolic process
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0098869cellular oxidant detoxification
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIBAGO:0005737cytoplasm
CCIDAGO:0016323basolateral plasma membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: LPO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LPO


DatabasePathway IDPathway Des.
kegghsa04970Salivary secretion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LPO

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