LPO
Summary: This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lactoperoxidase | MIM:150205 | Ensembl:ENSG00000167419 | HGNC:HGNC:6678 | PA30439 | 17q22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LPO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004601 | peroxidase activity |
| MF | IEA | GO:0020037 | heme binding |
| MF | IBA | GO:0036393 | thiocyanate peroxidase activity |
| MF | IDA | GO:0036393 | thiocyanate peroxidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IDA | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste |
| BP | NAS | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0018969 | thiocyanate metabolic process |
| BP | IBA | GO:0042742 | defense response to bacterium |
| BP | IDA | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0042744 | hydrogen peroxide catabolic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: LPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LPO
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.