MCF2L Summary: This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
GO terms in MCF2L Term Type Evidence Type GO Term ID GO Des. CC HDA GO:0005615 extracellular space CC TAS GO:0005829 cytosol CC IEA GO:0005886 plasma membrane CC IEA GO:0012505 endomembrane system BP TAS GO:0007186 G-protein coupled receptor signaling pathway BP IEA GO:0035023 regulation of Rho protein signal transduction BP IEA GO:0035556 intracellular signal transduction BP TAS GO:0043065 positive regulation of apoptotic process BP TAS GO:0051056 regulation of small GTPase mediated signal transduction MF TAS GO:0005085 guanyl-nucleotide exchange factor activity MF TAS GO:0005089 Rho guanyl-nucleotide exchange factor activity MF IDA GO:0035091 phosphatidylinositol binding
Gene expression in normal tissue: MCF2L
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
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Gene-model tissue-cancer distribution: Bubble Plot
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Gene-drug pathway distribution
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