MCF2L


Summary: This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MCF.2 cell line derived transforming sequence likeMIM:609499Ensembl:ENSG00000126217HGNC:HGNC:14576PA3068513q34

GO terms in MCF2L


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005615extracellular space
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIEAGO:0012505endomembrane system
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0043065positive regulation of apoptotic process
BPTASGO:0051056regulation of small GTPase mediated signal transduction
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
MFIDAGO:0035091phosphatidylinositol binding

Gene expression in normal tissue: MCF2L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCF2L


DatabasePathway IDPathway Des.
pidcdc42_reg_pathwayRegulation of CDC42 activity
pidrhoa_reg_pathwayRegulation of RhoA activity
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-73887Death Receptor Signalling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCF2L

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