MCF2L
Summary: This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MCF.2 cell line derived transforming sequence like | MIM:609499 | Ensembl:ENSG00000126217 | HGNC:HGNC:14576 | PA30685 | 13q34 |
GO terms in MCF2L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0012505 | endomembrane system |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: MCF2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCF2L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCF2L
CLASSFICATION
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