MIA2


Summary: This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MIA SH3 domain ER export factor 2MIM:602132Ensembl:ENSG00000150527HGNC:HGNC:18432PA3078814q21.1

GO terms in MIA2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006888ER to Golgi vesicle-mediated transport
BPIMPGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIBAGO:0009306protein secretion
BPIMPGO:0032527protein exit from endoplasmic reticulum
BPIBAGO:0035459cargo loading into vesicle
BPIMPGO:0035459cargo loading into vesicle
BPIEAGO:0043085positive regulation of catalytic activity
BPIMPGO:0070973protein localization to endoplasmic reticulum exit site
BPIDAGO:1905097regulation of guanyl-nucleotide exchange factor activity
CCIBAGO:0005789endoplasmic reticulum membrane
CCIEAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCHDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0070971endoplasmic reticulum exit site
CCIDAGO:0070971endoplasmic reticulum exit site
MFIPIGO:0005515protein binding
MFTASGO:0008047enzyme activator activity
MFIBAGO:0042954lipoprotein transporter activity

Gene expression in normal tissue: MIA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIA2


DatabasePathway IDPathway Des.
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5694530Cargo concentration in the ER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIA2

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