MICB
Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MHC class I polypeptide-related sequence B | MIM:602436 | Ensembl:ENSG00000204516 | HGNC:HGNC:7091 | PA30812 | 6p21.33 |
Gene Categories:
CELL SURFACEGO terms in MICB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0046703 | natural killer cell lectin-like receptor binding |
| MF | IDA | GO:0046703 | natural killer cell lectin-like receptor binding |
| BP | IBA | GO:0001913 | T cell mediated cytotoxicity |
| BP | IDA | GO:0002429 | immune response-activating cell surface receptor signaling pathway |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0006979 | response to oxidative stress |
| BP | IDA | GO:0009408 | response to heat |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0019835 | cytolysis |
| BP | IBA | GO:0030101 | natural killer cell activation |
| BP | IDA | GO:0032526 | response to retinoic acid |
| BP | IBA | GO:0042267 | natural killer cell mediated cytotoxicity |
| BP | IBA | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
| BP | IDA | GO:0046629 | gamma-delta T cell activation |
| BP | IDA | GO:0050689 | negative regulation of defense response to virus by host |
| BP | TAS | GO:0050776 | regulation of immune response |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: MICB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MICB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MICB
CLASSFICATION
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