MICB


Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MHC class I polypeptide-related sequence BMIM:602436Ensembl:ENSG00000204516HGNC:HGNC:7091PA308126p21.33

Gene Categories:

CELL SURFACE

GO terms in MICB


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0046703natural killer cell lectin-like receptor binding
MFIDAGO:0046703natural killer cell lectin-like receptor binding
BPIBAGO:0001913T cell mediated cytotoxicity
BPIDAGO:0002429immune response-activating cell surface receptor signaling pathway
BPIBAGO:0006955immune response
BPIDAGO:0006979response to oxidative stress
BPIDAGO:0009408response to heat
BPIEAGO:0016032viral process
BPIEAGO:0019835cytolysis
BPIBAGO:0030101natural killer cell activation
BPIDAGO:0032526response to retinoic acid
BPIBAGO:0042267natural killer cell mediated cytotoxicity
BPIBAGO:0042271susceptibility to natural killer cell mediated cytotoxicity
BPIDAGO:0046629gamma-delta T cell activation
BPIDAGO:0050689negative regulation of defense response to virus by host
BPTASGO:0050776regulation of immune response
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0009986cell surface
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: MICB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MICB


DatabasePathway IDPathway Des.
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657522

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MICB

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