Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

microRNA 181a-2MIM:612743Ensembl:ENSG00000207595HGNC:HGNC:31549PA1647225229q33.3

GO terms in MIR181A2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:1903231mRNA binding involved in posttranscriptional gene silencing
MFIMPGO:1903231mRNA binding involved in posttranscriptional gene silencing
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIEAGO:0035068micro-ribonucleoprotein complex
CCIDAGO:0045177apical part of cell
BPIGIGO:0010629negative regulation of gene expression
BPIMPGO:0030335positive regulation of cell migration
BPIDAGO:0035195gene silencing by miRNA
BPIEAGO:0035195gene silencing by miRNA
BPIMPGO:0035195gene silencing by miRNA
BPIMPGO:0035278miRNA mediated inhibition of translation
BPIDAGO:0045429positive regulation of nitric oxide biosynthetic process
BPIDAGO:0045603positive regulation of endothelial cell differentiation
BPIMPGO:1900745positive regulation of p38MAPK cascade

Gene expression in normal tissue: MIR181A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIR181A2

DatabasePathway IDPathway Des.
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2029Cell Differentiation - Index
wikipathwaysWP2059Alzheimers Disease

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIR181A2