MIR181A2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 181a-2 | MIM:612743 | Ensembl:ENSG00000207595 | HGNC:HGNC:31549 | PA164722522 | 9q33.3 |
GO terms in MIR181A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| MF | IMP | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | IDA | GO:0045177 | apical part of cell |
| BP | IGI | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035195 | gene silencing by miRNA |
| BP | IMP | GO:0035195 | gene silencing by miRNA |
| BP | IMP | GO:0035278 | miRNA mediated inhibition of translation |
| BP | IDA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0045603 | positive regulation of endothelial cell differentiation |
| BP | IMP | GO:1900745 | positive regulation of p38MAPK cascade |
Gene expression in normal tissue: MIR181A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR181A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP2059 | Alzheimers Disease |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR181A2
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