MIR24-2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 24-2 | MIM:610724 | Ensembl:ENSG00000284387 | HGNC:HGNC:31608 | PA164722616 | 19p13.12 |
GO terms in MIR24-2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| MF | IMP | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035195 | gene silencing by miRNA |
| BP | IMP | GO:0035195 | gene silencing by miRNA |
| BP | IDA | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| BP | ISS | GO:0061049 | cell growth involved in cardiac muscle cell development |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| BP | IDA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
| BP | IDA | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | ISS | GO:1904684 | negative regulation of metalloendopeptidase activity |
| BP | IDA | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process |
| BP | ISS | GO:1905522 | negative regulation of macrophage migration |
| BP | IDA | GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| BP | ISS | GO:2000270 | negative regulation of fibroblast apoptotic process |
| BP | IDA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
Gene expression in normal tissue: MIR24-2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR24-2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR24-2
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