Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

microRNA 24-2MIM:610724Ensembl:ENSG00000284387HGNC:HGNC:31608PA16472261619p13.12

GO terms in MIR24-2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:1903231mRNA binding involved in posttranscriptional gene silencing
MFIMPGO:1903231mRNA binding involved in posttranscriptional gene silencing
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIEAGO:0035068micro-ribonucleoprotein complex
CCIDAGO:0070062extracellular exosome
BPISSGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIDAGO:0016525negative regulation of angiogenesis
BPIDAGO:0035195gene silencing by miRNA
BPIEAGO:0035195gene silencing by miRNA
BPIMPGO:0035195gene silencing by miRNA
BPIDAGO:0043537negative regulation of blood vessel endothelial cell migration
BPISSGO:0061049cell growth involved in cardiac muscle cell development
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIDAGO:1903428positive regulation of reactive oxygen species biosynthetic process
BPIDAGO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPISSGO:1904684negative regulation of metalloendopeptidase activity
BPIDAGO:1905461positive regulation of vascular associated smooth muscle cell apoptotic process
BPISSGO:1905522negative regulation of macrophage migration
BPIDAGO:1905563negative regulation of vascular endothelial cell proliferation
BPISSGO:2000270negative regulation of fibroblast apoptotic process
BPIDAGO:2000353positive regulation of endothelial cell apoptotic process

Gene expression in normal tissue: MIR24-2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIR24-2

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIR24-2