MIR34C
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 34c | MIM:611375 | Ensembl:ENSG00000207562 | HGNC:HGNC:31637 | PA164722677 | 11q23.1 |
GO terms in MIR34C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0035195 | gene silencing by miRNA |
| BP | ISS | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | ISS | GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress |
| BP | ISS | GO:1903671 | negative regulation of sprouting angiogenesis |
| BP | ISS | GO:1905205 | positive regulation of connective tissue replacement |
Gene expression in normal tissue: MIR34C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR34C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP1438 | Influenza A virus infection |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2249 | Metastatic brain tumor |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2786 | Pre-NOTCH Expression and Processing |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3307 | MAPK6-MAPK4 signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR34C
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