GO terms in MLST8


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007050cell cycle arrest
BPTASGO:0016241regulation of macroautophagy
BPIEAGO:0030838positive regulation of actin filament polymerization
BPIBAGO:0031929TOR signaling
BPIMPGO:0032008positive regulation of TOR signaling
BPTASGO:0032148activation of protein kinase B activity
BPIBAGO:0032956regulation of actin cytoskeleton organization
BPIMPGO:0032956regulation of actin cytoskeleton organization
BPIMPGO:0038202TORC1 signaling
BPIEAGO:0043087regulation of GTPase activity
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0071902positive regulation of protein serine/threonine kinase activity
BPTASGO:1900034regulation of cellular response to heat
CCTASGO:0005654nucleoplasm
CCISSGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0031931TORC1 complex
CCIDAGO:0031931TORC1 complex
CCIBAGO:0031932TORC2 complex
CCIDAGO:0031932TORC2 complex
MFIPIGO:0005515protein binding
MFIDAGO:0043539protein serine/threonine kinase activator activity

Gene expression in normal tissue: MLST8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MLST8


DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP615Senescence and Autophagy in Cancer
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidlkb1_pathwayLKB1 signaling events
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
kegghsa04136Autophagy - other - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1632852Macroautophagy
reactomeR-HSA-1643685Disease
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-166208mTORC1-mediated signalling
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPK
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MLST8

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