MRAP2


Summary: This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
melanocortin 2 receptor accessory protein 2MIM:615410Ensembl:ENSG00000135324HGNC:HGNC:21232PA1623961616q14.2

GO terms in MRAP2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0031780corticotropin hormone receptor binding
MFIPIGO:0031781type 3 melanocortin receptor binding
MFIPIGO:0031782type 4 melanocortin receptor binding
MFIPIGO:0031783type 5 melanocortin receptor binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0070996type 1 melanocortin receptor binding
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPISSGO:0006112energy reserve metabolic process
BPISSGO:0007631feeding behavior
BPIDAGO:0072659protein localization to plasma membrane
BPISSGO:0097009energy homeostasis
BPIDAGO:0106071positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPIDAGO:0106072negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPIDAGO:1903077negative regulation of protein localization to plasma membrane

Gene expression in normal tissue: MRAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRAP2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRAP2

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