MRAP2
Summary: This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| melanocortin 2 receptor accessory protein 2 | MIM:615410 | Ensembl:ENSG00000135324 | HGNC:HGNC:21232 | PA162396161 | 6q14.2 |
GO terms in MRAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031780 | corticotropin hormone receptor binding |
| MF | IPI | GO:0031781 | type 3 melanocortin receptor binding |
| MF | IPI | GO:0031782 | type 4 melanocortin receptor binding |
| MF | IPI | GO:0031783 | type 5 melanocortin receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0070996 | type 1 melanocortin receptor binding |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | ISS | GO:0006112 | energy reserve metabolic process |
| BP | ISS | GO:0007631 | feeding behavior |
| BP | IDA | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | IDA | GO:0106071 | positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0106072 | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | IDA | GO:1903077 | negative regulation of protein localization to plasma membrane |
Gene expression in normal tissue: MRAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRAP2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRAP2
CLASSFICATION
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