MRPS27
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitochondrial ribosomal protein S27 | MIM:611989 | Ensembl:ENSG00000113048 | HGNC:HGNC:14512 | PA31015 | 5q13.2 |
GO terms in MRPS27
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000049 | tRNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019843 | rRNA binding |
| MF | IDA | GO:0097177 | mitochondrial ribosome binding |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | TAS | GO:0070125 | mitochondrial translational elongation |
| BP | TAS | GO:0070126 | mitochondrial translational termination |
| BP | IMP | GO:0070131 | positive regulation of mitochondrial translation |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005763 | mitochondrial small ribosomal subunit |
Gene expression in normal tissue: MRPS27
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRPS27
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5368286 | Mitochondrial translation initiation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5419276 | Mitochondrial translation termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRPS27
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.