MRPS27


Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitochondrial ribosomal protein S27MIM:611989Ensembl:ENSG00000113048HGNC:HGNC:14512PA310155q13.2

GO terms in MRPS27


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000049tRNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0019843rRNA binding
MFIDAGO:0097177mitochondrial ribosome binding
BPIMPGO:0008283cell proliferation
BPTASGO:0070125mitochondrial translational elongation
BPTASGO:0070126mitochondrial translational termination
BPIMPGO:0070131positive regulation of mitochondrial translation
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCTASGO:0005743mitochondrial inner membrane
CCIDAGO:0005763mitochondrial small ribosomal subunit

Gene expression in normal tissue: MRPS27

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRPS27


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5368286Mitochondrial translation initiation
reactomeR-HSA-5368287Mitochondrial translation
reactomeR-HSA-5368287Mitochondrial translation
reactomeR-HSA-5389840Mitochondrial translation elongation
reactomeR-HSA-5389840Mitochondrial translation elongation
reactomeR-HSA-5419276Mitochondrial translation termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRPS27

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