MSRA
Summary: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
methionine sulfoxide reductase A | MIM:601250 | Ensembl:ENSG00000175806 | HGNC:HGNC:7377 | PA31182 | 8p23.1 |
GO terms in MSRA
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
BP | TAS | GO:0006464 | cellular protein modification process |
BP | TAS | GO:0006555 | methionine metabolic process |
BP | TAS | GO:0006979 | response to oxidative stress |
BP | TAS | GO:0030091 | protein repair |
BP | IEA | GO:0055114 | oxidation-reduction process |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IEA | GO:0005739 | mitochondrion |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0015629 | actin cytoskeleton |
CC | IEA | GO:0016020 | membrane |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: MSRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MSRA
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-5676934 | Protein repair |
wikipathways | WP2542 | Sulindac Metabolic Pathway |
wikipathways | WP3580 | Methionine De Novo and Salvage Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MSRA