MSRA


Summary: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
methionine sulfoxide reductase AMIM:601250Ensembl:ENSG00000175806HGNC:HGNC:7377PA311828p23.1

GO terms in MSRA


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0008113peptide-methionine (S)-S-oxide reductase activity
BPTASGO:0006464cellular protein modification process
BPTASGO:0006555methionine metabolic process
BPTASGO:0006979response to oxidative stress
BPTASGO:0030091protein repair
BPIEAGO:0055114oxidation-reduction process
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0015629actin cytoskeleton
CCIEAGO:0016020membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: MSRA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSRA


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5676934Protein repair
wikipathwaysWP2542Sulindac Metabolic Pathway
wikipathwaysWP3580Methionine De Novo and Salvage Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSRA

​​​​