NEURL1


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neuralized E3 ubiquitin protein ligase 1MIM:603804Ensembl:ENSG00000107954HGNC:HGNC:7761PA3156310q24.33

Gene Categories:

TYROSINE KINASEKINASE

GO terms in NEURL1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005886plasma membrane
CCISSGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCISSGO:0043197dendritic spine
CCISSGO:0043204perikaryon
CCIEAGO:0045211postsynaptic membrane
CCIEAGO:0048471perinuclear region of cytoplasm
CCISSGO:0097440apical dendrite
BPIEAGO:0006417regulation of translation
BPISSGO:0006513protein monoubiquitination
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0007288sperm axoneme assembly
BPTASGO:0007399nervous system development
BPIEAGO:0007420brain development
BPIEAGO:0007519skeletal muscle tissue development
BPIEAGO:0007595lactation
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0045741positive regulation of epidermal growth factor-activated receptor activity
BPIDAGO:0045746negative regulation of Notch signaling pathway
BPISSGO:0048170positive regulation of long-term neuronal synaptic plasticity
BPISSGO:0051491positive regulation of filopodium assembly
BPISSGO:0060999positive regulation of dendritic spine development
BPISSGO:0071230cellular response to amino acid stimulus
BPISSGO:0090129positive regulation of synapse maturation
MFISSGO:0004842ubiquitin-protein transferase activity
MFISSGO:0045183translation factor activity, non-nucleic acid binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: NEURL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEURL1


DatabasePathway IDPathway Des.
pidnotch_pathwayNotch signaling pathway
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in Cancer
reactomeR-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521
iGMDRD30917AAG1
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEURL1

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