NFE2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor, erythroid 2 | MIM:601490 | Ensembl:ENSG00000123405 | HGNC:HGNC:7780 | PA31586 | 12q13.13 |
GO terms in NFE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006337 | nucleosome disassembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0007599 | hemostasis |
| BP | TAS | GO:0008015 | blood circulation |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IBA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | TAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016605 | PML body |
| CC | IDA | GO:0032993 | protein-DNA complex |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IDA | GO:0050699 | WW domain binding |
| MF | IPI | GO:0050699 | WW domain binding |
Gene expression in normal tissue: NFE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFE2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4132 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFE2
CLASSFICATION
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