NR4A2


Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor subfamily 4 group A member 2MIM:601828Ensembl:ENSG00000153234HGNC:HGNC:7981PA317622q24.1

GO terms in NR4A2


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001666response to hypoxia
BPTASGO:0001764neuron migration
BPIEAGO:0001975response to amphetamine
BPIDAGO:0006351transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPNASGO:0007165signal transduction
BPIEAGO:0008344adult locomotory behavior
BPIEAGO:0009791post-embryonic development
BPIEAGO:0021952central nervous system projection neuron axonogenesis
BPIBAGO:0021953central nervous system neuron differentiation
BPIEAGO:0021986habenula development
BPIEAGO:0030522intracellular receptor signaling pathway
BPIDAGO:0031668cellular response to extracellular stimulus
BPIEAGO:0034599cellular response to oxidative stress
BPIEAGO:0042053regulation of dopamine metabolic process
BPIEAGO:0042416dopamine biosynthetic process
BPIEAGO:0042551neuron maturation
BPIEAGO:0043085positive regulation of catalytic activity
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0043576regulation of respiratory gaseous exchange
BPISSGO:0045444fat cell differentiation
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051866general adaptation syndrome
BPTASGO:0060070canonical Wnt signaling pathway
BPIBAGO:0071376cellular response to corticotropin-releasing hormone stimulus
BPISSGO:0071376cellular response to corticotropin-releasing hormone stimulus
BPIBAGO:0071542dopaminergic neuron differentiation
BPISSGO:0071542dopaminergic neuron differentiation
BPTASGO:1904948midbrain dopaminergic neuron differentiation
BPIMPGO:2001234negative regulation of apoptotic signaling pathway
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005737cytoplasm
CCIDAGO:0016607nuclear speck
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFIEAGO:0003707steroid hormone receptor activity
MFTASGO:0004879nuclear receptor activity
MFIPIGO:0005515protein binding
MFTASGO:0008013beta-catenin binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0035259glucocorticoid receptor binding
MFIEAGO:0035259glucocorticoid receptor binding
MFTASGO:0042803protein homodimerization activity
MFIBAGO:0043565sequence-specific DNA binding
MFTASGO:0046965retinoid X receptor binding
MFISSGO:0046982protein heterodimerization activity
MFTASGO:0046982protein heterodimerization activity

Gene expression in normal tissue: NR4A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR4A2


DatabasePathway IDPathway Des.
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR4A2

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