NR4A2
Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601828 Ensembl IDEnsembl:ENSG00000153234 HGNC IDHGNC:HGNC:7981 PHARMGKB IDPA31762 Map Location2q24.1 | |||||
GO terms in NR4A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0001764 | neuron migration |
| BP | IEA | GO:0001975 | response to amphetamine |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
Gene expression in normal tissue: NR4A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR4A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2855 | Dopaminergic Neurogenesis |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR4A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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