NR4A2


Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].

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GO terms in NR4A2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000122 negative regulation of transcription by RNA polymerase II
BP TAS GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001666 response to hypoxia
BP TAS GO:0001764 neuron migration
BP IEA GO:0001975 response to amphetamine
BP IDA GO:0006351 transcription, DNA-templated
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Gene expression in normal tissue: NR4A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Chromatin histone acetylation1

Pathways in NR4A2


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Database
Pathway ID
Pathway Des.
wikipathways WP170 Nuclear Receptors
wikipathways WP2355 Corticotropin-releasing hormone signaling pathway
wikipathways WP2855 Dopaminergic Neurogenesis
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
kegg hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
reactome R-HSA-212436 Generic Transcription Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD289 Parthenolide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR4A2

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Model
Level
Reference ID
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Cancer
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Source
No matching records found

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