NTN4


Summary: This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
netrin 4MIM:610401Ensembl:ENSG00000074527HGNC:HGNC:13658PA3181512q22

Gene Categories:

DRUGGABLE GENOME

GO terms in NTN4


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0043237laminin-1 binding
CCIEAGO:0005604basement membrane
CCTASGO:0005886plasma membrane
BPTASGO:0007411axon guidance
BPIEAGO:0016322neuron remodeling
BPIEAGO:0060668regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling

Gene expression in normal tissue: NTN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTN4


DatabasePathway IDPathway Des.
kegghsa04360Axon guidance - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTN4

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