NVL
Summary: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear VCP-like | MIM:602426 | Ensembl:ENSG00000143748 | HGNC:HGNC:8070 | PA31857 | 1q42.11 |
Gene Categories:
RNA DIRECTED DNA POLYMERASEGO terms in NVL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005697 | telomerase holoenzyme complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | HDA | GO:0016020 | membrane |
| BP | IBA | GO:0042254 | ribosome biogenesis |
| BP | IMP | GO:0042254 | ribosome biogenesis |
| BP | IBA | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005524 | ATP binding |
| MF | IBA | GO:0016887 | ATPase activity |
| MF | IBA | GO:1990275 | preribosome binding |
| MF | IDA | GO:1990275 | preribosome binding |
Gene expression in normal tissue: NVL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NVL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NVL
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