OLR1
Summary: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| oxidized low density lipoprotein receptor 1 | MIM:602601 | Ensembl:ENSG00000173391 | HGNC:HGNC:8133 | PA31920 | 12p13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in OLR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030246 | carbohydrate binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| BP | TAS | GO:0006508 | proteolysis |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0008015 | blood circulation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0050900 | leukocyte migration |
Gene expression in normal tissue: OLR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OLR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP3942 | PPAR signaling pathway |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OLR1
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