OR2L8


Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
olfactory receptor family 2 subfamily L member 8 (gene/pseudogene)Ensembl:ENSG00000279263HGNC:HGNC:15014PA321891q44

GO terms in OR2L8


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIEAGO:0004930G-protein coupled receptor activity
MFIBAGO:0004984olfactory receptor activity
BPNDGO:0008150biological_process
BPIEAGO:0050911detection of chemical stimulus involved in sensory perception of smell
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: OR2L8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OR2L8


DatabasePathway IDPathway Des.
kegghsa04740Olfactory transduction - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381753Olfactory Signaling Pathway
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OR2L8

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