OR2S2


Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
olfactory receptor family 2 subfamily S member 2 (gene/pseudogene)Ensembl:ENSG00000278889HGNC:HGNC:8276PA322009p13.3

GO terms in OR2S2


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007608sensory perception of smell
BPIEAGO:0050911detection of chemical stimulus involved in sensory perception of smell
CCTASGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
MFIEAGO:0004930G-protein coupled receptor activity
MFIBAGO:0004984olfactory receptor activity
MFNASGO:0004984olfactory receptor activity

Gene expression in normal tissue: OR2S2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OR2S2


DatabasePathway IDPathway Des.
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
kegghsa04740Olfactory transduction - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381753Olfactory Signaling Pathway
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OR2S2

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