Summary: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013].

purinergic receptor P2Y2MIM:600041Ensembl:ENSG00000175591HGNC:HGNC:8541PA3287011q13.4

GO terms in P2RY2

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0038023signaling receptor activity
MFIEAGO:0045028G-protein coupled purinergic nucleotide receptor activity
BPTASGO:0006873cellular ion homeostasis
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway
BPIEAGO:0035589G-protein coupled purinergic nucleotide receptor signaling pathway
BPIEAGO:0070257positive regulation of mucus secretion
BPIEAGO:0097746regulation of blood vessel diameter
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane

Gene expression in normal tissue: P2RY2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in P2RY2

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-417957P2Y receptors
reactomeR-HSA-418038Nucleotide-like (purinergic) receptors
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-5683826Surfactant metabolism
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartaionpathwayionomycin and phorbal ester signaling pathway
biocartaraccpathwayion channels and their functional role in vascular endothelium
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP80Nucleotide GPCRs

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in P2RY2