PAPPA2


Summary: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pappalysin 2Ensembl:ENSG00000116183HGNC:HGNC:14615PA333731q25.2

GO terms in PAPPA2


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004222metalloendopeptidase activity
MFTASGO:0004222metalloendopeptidase activity
MFIDAGO:0008237metallopeptidase activity
MFNASGO:0008270zinc ion binding
BPNASGO:0001558regulation of cell growth
BPIDAGO:0006508proteolysis
BPIEAGO:0009651response to salt stress
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0060349bone morphogenesis
CCTASGO:0005576extracellular region
CCNASGO:0005622intracellular
CCIEAGO:0005829cytosol
CCIEAGO:0016324apical plasma membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: PAPPA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAPPA2


DatabasePathway IDPathway Des.
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAPPA2

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