Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].

protocadherin alpha 4MIM:606310Ensembl:ENSG00000204967HGNC:HGNC:8670PA330165q31.3

GO terms in PCDHA4

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFISSGO:0042802identical protein binding
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
BPIBAGO:0007155cell adhesion
BPTASGO:0007155cell adhesion
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007267cell-cell signaling
BPTASGO:0007399nervous system development

Gene expression in normal tissue: PCDHA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCDHA4

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCDHA4