PCLO


Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
piccolo presynaptic cytomatrix proteinMIM:604918Ensembl:ENSG00000186472HGNC:HGNC:13406PA330727q21.11

GO terms in PCLO


Term TypeEvidence TypeGO Term IDGO Des.
CCNASGO:0005856cytoskeleton
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCISSGO:0045202synapse
CCTASGO:0048788cytoskeleton of presynaptic active zone
CCHDAGO:0070062extracellular exosome
BPISSGO:0007010cytoskeleton organization
BPIEAGO:0007416synapse assembly
BPNASGO:0016079synaptic vesicle exocytosis
BPIEAGO:0017157regulation of exocytosis
BPIEAGO:0019933cAMP-mediated signaling
BPIEAGO:0030073insulin secretion
BPIEAGO:0035418protein localization to synapse
BPIEAGO:0099526presynapse to nucleus signaling pathway
MFISSGO:0005509calcium ion binding
MFISSGO:0005522profilin binding
MFISSGO:0005544calcium-dependent phospholipid binding

Gene expression in normal tissue: PCLO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCLO


DatabasePathway IDPathway Des.
kegghsa04911Insulin secretion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2
iGMDRD353PD03259011
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCLO

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