PCSK1N
Summary: The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| proprotein convertase subtilisin/kexin type 1 inhibitor | MIM:300399 | Ensembl:ENSG00000102109 | HGNC:HGNC:17301 | PA33090 | Xp11.23 |
GO terms in PCSK1N
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005802 | trans-Golgi network |
| CC | IEA | GO:0030141 | secretory granule |
| BP | IEA | GO:0002021 | response to dietary excess |
| BP | IEA | GO:0007218 | neuropeptide signaling pathway |
| BP | IEA | GO:0009409 | response to cold |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0016486 | peptide hormone processing |
| MF | IBA | GO:0004866 | endopeptidase inhibitor activity |
| MF | TAS | GO:0004866 | endopeptidase inhibitor activity |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | TAS | GO:0005102 | signaling receptor binding |
Gene expression in normal tissue: PCSK1N
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCSK1N
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCSK1N
CLASSFICATION
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