PCYT1B
Summary: The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphate cytidylyltransferase 1, choline, beta | MIM:300948 | Ensembl:ENSG00000102230 | HGNC:HGNC:8755 | PA33100 | Xp22.11 |
GO terms in PCYT1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001541 | ovarian follicle development |
| BP | TAS | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | IEA | GO:0006657 | CDP-choline pathway |
| BP | IEA | GO:0007283 | spermatogenesis |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| MF | IBA | GO:0004105 | choline-phosphate cytidylyltransferase activity |
| MF | TAS | GO:0004105 | choline-phosphate cytidylyltransferase activity |
| MF | IBA | GO:0031210 | phosphatidylcholine binding |
Gene expression in normal tissue: PCYT1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCYT1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483191 | Synthesis of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| wikipathways | WP3933 | Kennedy pathway from Sphingolipids |
| wikipathways | WP3940 | One carbon metabolism and related pathways |
| humancyc | PWY3O-450 | phosphatidylcholine biosynthesis |
| kegg | hsa00440 | Phosphonate and phosphinate metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCYT1B
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.