PDE9A


Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphodiesterase 9AMIM:602973Ensembl:ENSG00000160191HGNC:HGNC:8795PA3314321q22.3

Gene Categories:

DRUGGABLE GENOME

GO terms in PDE9A


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:00041143',5'-cyclic-nucleotide phosphodiesterase activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIDAGO:00475553',5'-cyclic-GMP phosphodiesterase activity
MFTASGO:00475553',5'-cyclic-GMP phosphodiesterase activity
BPTASGO:0007165signal transduction
BPISSGO:0010613positive regulation of cardiac muscle hypertrophy
BPIEAGO:0019934cGMP-mediated signaling
BPIDAGO:0046068cGMP metabolic process
BPIDAGO:0046069cGMP catabolic process
BPIEAGO:0046069cGMP catabolic process
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCHDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0032587ruffle membrane
CCIDAGO:0042383sarcolemma
CCIEAGO:0043204perikaryon
CCIEAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: PDE9A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDE9A


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects
pidar_tf_pathwayRegulation of Androgen receptor activity
kegghsa00230Purine metabolism - Homo sapiens (human)
wikipathwaysWP4222Phosphodiesterases in neuronal function

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDE9A

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