Summary: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010].

phosphorylase kinase regulatory subunit betaMIM:172490Ensembl:ENSG00000102893HGNC:HGNC:8927PA3326816q12.1

GO terms in PHKB

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005886plasma membrane
CCIBAGO:0005964phosphorylase kinase complex
BPIEAGO:0005977glycogen metabolic process
BPTASGO:0006091generation of precursor metabolites and energy
BPIBAGO:0006468protein phosphorylation
BPIEAGO:0006468protein phosphorylation
MFIBAGO:0004689phosphorylase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding

Gene expression in normal tissue: PHKB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHKB

DatabasePathway IDPathway Des.
wikipathwaysWP500Glycogen Metabolism
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
reactomeR-HSA-70221Glycogen breakdown (glycogenolysis)
reactomeR-HSA-70221Glycogen breakdown (glycogenolysis)
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-8982491Glycogen metabolism
reactomeR-HSA-8982491Glycogen metabolism

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHKB