PIGX
Summary: This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol glycan anchor biosynthesis class X | MIM:610276 | Ensembl:ENSG00000163964 | HGNC:HGNC:26046 | PA134928970 | 3q29 |
GO terms in PIGX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006506 | GPI anchor biosynthetic process |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: PIGX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIGX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-162710 | Synthesis of glycosylphosphatidylinositol (GPI) |
| reactome | R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIGX
CLASSFICATION
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