PIM3
Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Pim-3 proto-oncogene, serine/threonine kinase | MIM:610580 | Ensembl:ENSG00000198355 | HGNC:HGNC:19310 | PA134980758 | 22q13.33 |
GO terms in PIM3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
CC | IBA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
BP | IDA | GO:0006468 | protein phosphorylation |
BP | IEA | GO:0006915 | apoptotic process |
BP | IEA | GO:0007049 | cell cycle |
BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
BP | IBA | GO:0043066 | negative regulation of apoptotic process |
BP | IMP | GO:0043066 | negative regulation of apoptotic process |
BP | IBA | GO:0046777 | protein autophosphorylation |
BP | ISS | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus |
Gene expression in normal tissue: PIM3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIM3
Database | Pathway ID | Pathway Des. |
---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIM3