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PIM3

Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Pim-3 proto-oncogene, serine/threonine kinase	MIM:610580	Ensembl:ENSG00000198355	HGNC:HGNC:19310	PA134980758	22q13.33

Gene Categories:

DRUGGABLE GENOME KINASE TUMOR SUPPRESSOR SERINE THREONINE KINASE

GO terms in PIM3

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
BP	IDA	GO:0006468	protein phosphorylation
BP	IEA	GO:0006915	apoptotic process
BP	IEA	GO:0007049	cell cycle
BP	IBA	GO:0007346	regulation of mitotic cell cycle
BP	IMP	GO:0007346	regulation of mitotic cell cycle
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IBA	GO:0046777	protein autophosphorylation
BP	ISS	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Gene expression in normal tissue: PIM3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIM3

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD137	Indisulam	9

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIM3

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.