PLCB1
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase C beta 1 | MIM:607120 | Ensembl:ENSG00000182621 | HGNC:HGNC:15917 | PA33384 | 20p12.3 |
GO terms in PLCB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | NAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004629 | phospholipase C activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005521 | lamin binding |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| CC | ISS | GO:0000790 | nuclear chromatin |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway |
| BP | ISS | GO:0007215 | glutamate receptor signaling pathway |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | ISS | GO:0007613 | memory |
| BP | ISS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | ISS | GO:0021987 | cerebral cortex development |
| BP | ISS | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IDA | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | ISS | GO:0040019 | positive regulation of embryonic development |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IEA | GO:0045444 | fat cell differentiation |
| BP | ISS | GO:0045663 | positive regulation of myoblast differentiation |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046488 | phosphatidylinositol metabolic process |
| BP | ISS | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| BP | ISS | GO:0048639 | positive regulation of developmental growth |
| BP | ISS | GO:0060466 | activation of meiosis involved in egg activation |
| BP | IDA | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | ISS | GO:0080154 | regulation of fertilization |
| BP | ISS | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| BP | ISS | GO:2000344 | positive regulation of acrosome reaction |
| BP | ISS | GO:2000438 | negative regulation of monocyte extravasation |
| BP | ISS | GO:2000560 | positive regulation of CD24 biosynthetic process |
Gene expression in normal tissue: PLCB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| netpath | Pathway_IL2 | IL2 |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-399997 | Acetylcholine regulates insulin secretion |
| reactome | R-HSA-399997 | Acetylcholine regulates insulin secretion |
| reactome | R-HSA-400451 | Free fatty acids regulate insulin secretion |
| reactome | R-HSA-400451 | Free fatty acids regulate insulin secretion |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418217 | G beta:gamma signalling through PLC beta |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion |
| reactome | R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| reactome | R-HSA-500657 | Presynaptic function of Kainate receptors |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| biocarta | eicosanoidpathway | eicosanoid metabolism |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | pkcpathway | activation of pkc through g-protein coupled receptors |
| biocarta | plcpathway | phospholipase c signaling pathway |
| biocarta | sppapathway | aspirin blocks signaling pathway involved in platelet activation |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | endothelinpathway | Endothelins |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA161749006 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP3679 | Cell-type Dependent Selectivity of CCK2R Signaling |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3958 | GPR40 Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCB1
CLASSFICATION
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