PLCH2


Summary: PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phospholipase C eta 2MIM:612836Ensembl:ENSG00000149527HGNC:HGNC:29037PA1349144711p36.32

GO terms in PLCH2


Term TypeEvidence TypeGO Term IDGO Des.
BPNDGO:0008150biological_process
BPIEAGO:0016042lipid catabolic process
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0043647inositol phosphate metabolic process
BPIEAGO:0046488phosphatidylinositol metabolic process
CCNDGO:0005575cellular_component
CCIEAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
MFNDGO:0003674molecular_function
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFIEAGO:0005509calcium ion binding

Gene expression in normal tissue: PLCH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLCH2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
humancycLIPASYN-PWYphospholipases
humancycPWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancycPWY-6367D-myo-inositol-5-phosphate metabolism
humancycPWY-6371superpathway of inositol phosphate compounds
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCH2

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