POU2F1


Summary: The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
POU class 2 homeobox 1MIM:164175Ensembl:ENSG00000143190HGNC:HGNC:9212PA335361q24.2

GO terms in POU2F1


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0000979RNA polymerase II core promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIMPGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0043565sequence-specific DNA binding
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIMPGO:0090575RNA polymerase II transcription factor complex
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: POU2F1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POU2F1


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74158RNA Polymerase III Transcription
reactomeR-HSA-74158RNA Polymerase III Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-749476RNA Polymerase III Abortive And Retractive Initiation
reactomeR-HSA-76046RNA Polymerase III Transcription Initiation
reactomeR-HSA-76046RNA Polymerase III Transcription Initiation
reactomeR-HSA-76071RNA Polymerase III Transcription Initiation From Type 3 Promoter
reactomeR-HSA-76071RNA Polymerase III Transcription Initiation From Type 3 Promoter
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
pidar_tf_pathwayRegulation of Androgen receptor activity
pidatf2_pathwayATF-2 transcription factor network
pidhnf3apathwayFOXA1 transcription factor network
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
wikipathwaysWP1971Integrated Cancer Pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POU2F1

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