POU2F2


Summary: The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
POU class 2 homeobox 2MIM:164176Ensembl:ENSG00000028277HGNC:HGNC:9213PA3353719q13.2

GO terms in POU2F2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0019904protein domain specific binding
MFIDAGO:0043565sequence-specific DNA binding
BPIEAGO:0002335mature B cell differentiation
BPIEAGO:0002380immunoglobulin secretion involved in immune response
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006959humoral immune response
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048469cell maturation
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIDAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: POU2F2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POU2F2


DatabasePathway IDPathway Des.
pidbcr_5pathwayBCR signaling pathway
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG1
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POU2F2

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