PRCP
Summary: This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prolylcarboxypeptidase | MIM:176785 | Ensembl:ENSG00000137509 | HGNC:HGNC:9344 | PA33705 | 11q14.1 |
GO terms in PRCP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004185 | serine-type carboxypeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008239 | dipeptidyl-peptidase activity |
| BP | IEA | GO:0002155 | regulation of thyroid hormone mediated signaling pathway |
| BP | IEA | GO:0002353 | plasma kallikrein-kinin cascade |
| BP | IBA | GO:0003085 | negative regulation of systemic arterial blood pressure |
| BP | IBA | GO:0006508 | proteolysis |
| BP | TAS | GO:0007597 | blood coagulation, intrinsic pathway |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0043535 | regulation of blood vessel endothelial cell migration |
| BP | IBA | GO:0060055 | angiogenesis involved in wound healing |
| BP | IEA | GO:0097009 | energy homeostasis |
| BP | IEA | GO:2000377 | regulation of reactive oxygen species metabolic process |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IEA | GO:0045178 | basal part of cell |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
Gene expression in normal tissue: PRCP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRCP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation |
| reactome | R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04614 | Renin-angiotensin system - Homo sapiens (human) |
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRCP
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