PROM2
Summary: This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prominin 2 | MIM:617160 | Ensembl:ENSG00000155066 | HGNC:HGNC:20685 | PA134861956 | 2q11.1 |
Gene Categories:
CELL SURFACEGO terms in PROM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005902 | microvillus |
| CC | ISS | GO:0005902 | microvillus |
| CC | IBA | GO:0005929 | cilium |
| CC | ISS | GO:0005929 | cilium |
| CC | IBA | GO:0009986 | cell surface |
| CC | ISS | GO:0009986 | cell surface |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IBA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0031528 | microvillus membrane |
| CC | IDA | GO:0042995 | cell projection |
| CC | ISS | GO:0044393 | microspike |
| CC | ISS | GO:0045121 | membrane raft |
| CC | IEA | GO:0060170 | ciliary membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IBA | GO:0071914 | prominosome |
| CC | ISS | GO:0071914 | prominosome |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0031346 | positive regulation of cell projection organization |
| BP | IDA | GO:0043087 | regulation of GTPase activity |
| BP | IDA | GO:0048550 | negative regulation of pinocytosis |
| BP | IDA | GO:2000369 | regulation of clathrin-dependent endocytosis |
| BP | IDA | GO:2001287 | negative regulation of caveolin-mediated endocytosis |
| MF | IBA | GO:0015485 | cholesterol binding |
| MF | ISS | GO:0015485 | cholesterol binding |
Gene expression in normal tissue: PROM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PROM2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PROM2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.