PROM2


Summary: This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
prominin 2MIM:617160Ensembl:ENSG00000155066HGNC:HGNC:20685PA1348619562q11.1

Gene Categories:

CELL SURFACE

GO terms in PROM2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIBAGO:0005902microvillus
CCISSGO:0005902microvillus
CCIBAGO:0005929cilium
CCISSGO:0005929cilium
CCIBAGO:0009986cell surface
CCISSGO:0009986cell surface
CCIEAGO:0016323basolateral plasma membrane
CCIBAGO:0016324apical plasma membrane
CCIEAGO:0016324apical plasma membrane
CCISSGO:0031410cytoplasmic vesicle
CCIEAGO:0031528microvillus membrane
CCIDAGO:0042995cell projection
CCISSGO:0044393microspike
CCISSGO:0045121membrane raft
CCIEAGO:0060170ciliary membrane
CCHDAGO:0070062extracellular exosome
CCIBAGO:0071914prominosome
CCISSGO:0071914prominosome
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0031346positive regulation of cell projection organization
BPIDAGO:0043087regulation of GTPase activity
BPIDAGO:0048550negative regulation of pinocytosis
BPIDAGO:2000369regulation of clathrin-dependent endocytosis
BPIDAGO:2001287negative regulation of caveolin-mediated endocytosis
MFIBAGO:0015485cholesterol binding
MFISSGO:0015485cholesterol binding

Gene expression in normal tissue: PROM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PROM2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PROM2

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