PRPSAP2


Summary: This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphoribosyl pyrophosphate synthetase associated protein 2MIM:603762Ensembl:ENSG00000141127HGNC:HGNC:9467PA3382217p11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in PRPSAP2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0002189ribose phosphate diphosphokinase complex
CCIBAGO:0005737cytoplasm
BPIBAGO:00060155-phosphoribose 1-diphosphate biosynthetic process
BPTASGO:0006139nucleobase-containing compound metabolic process
BPIBAGO:0006164purine nucleotide biosynthetic process
BPIEAGO:0009116nucleoside metabolic process
BPIBAGO:0009165nucleotide biosynthetic process
BPIEAGO:0009165nucleotide biosynthetic process
BPIEAGO:0043086negative regulation of catalytic activity
BPIEAGO:0060348bone development
MFIEAGO:0000287magnesium ion binding
MFIEAGO:0004749ribose phosphate diphosphokinase activity
MFTASGO:0004857enzyme inhibitor activity
MFIPIGO:0005515protein binding
MFIBAGO:0030234enzyme regulator activity

Gene expression in normal tissue: PRPSAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRPSAP2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRPSAP2

​​​​