PTPRN


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine phosphatase, receptor type NMIM:601773Ensembl:ENSG00000054356HGNC:HGNC:9676PA340212q35

GO terms in PTPRN


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0004725protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0030507spectrin binding
MFIDAGO:0044389ubiquitin-like protein ligase binding
MFIEAGO:0051020GTPase binding
CCIDAGO:0005634nucleus
CCISSGO:0005768endosome
CCISSGO:0005794Golgi apparatus
CCISSGO:0005886plasma membrane
CCISSGO:0008021synaptic vesicle
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030054cell junction
CCISSGO:0030141secretory granule
CCIEAGO:0030658transport vesicle membrane
CCISSGO:0043025neuronal cell body
CCIEAGO:0043204perikaryon
CCISSGO:0043679axon terminus
CCISSGO:0045202synapse
BPIDAGO:0000302response to reactive oxygen species
BPISSGO:0001553luteinization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0019221cytokine-mediated signaling pathway
BPIGIGO:0030073insulin secretion
BPIEAGO:0032868response to insulin
BPISSGO:0035773insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0043627response to estrogen
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051591response to cAMP
BPIDAGO:1904692positive regulation of type B pancreatic cell proliferation
BPIGIGO:1990502dense core granule maturation

Gene expression in normal tissue: PTPRN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRN


DatabasePathway IDPathway Des.
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRN

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