PYHIN1
Summary: The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pyrin and HIN domain family member 1 | MIM:612677 | Ensembl:ENSG00000163564 | HGNC:HGNC:28894 | PA134967485 | 1q23.1 |
GO terms in PYHIN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | IMP | GO:0035457 | cellular response to interferon-alpha |
| BP | IDA | GO:0043388 | positive regulation of DNA binding |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IDA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IDA | GO:1902164 | positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| BP | IDA | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: PYHIN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PYHIN1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PYHIN1
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