RAD17
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAD17 checkpoint clamp loader component | MIM:603139 | Ensembl:ENSG00000152942 | HGNC:HGNC:9807 | PA34167 | 5q13.2 |
GO terms in RAD17
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0031389 | Rad17 RFC-like complex |
| BP | TAS | GO:0000076 | DNA replication checkpoint |
| BP | IBA | GO:0000077 | DNA damage checkpoint |
| BP | IMP | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006281 | DNA repair |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IMP | GO:0008156 | negative regulation of DNA replication |
| BP | IBA | GO:0033314 | mitotic DNA replication checkpoint |
| BP | IMP | GO:0042325 | regulation of phosphorylation |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003689 | DNA clamp loader activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: RAD17
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD17
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP707 | DNA Damage Response |
| pid | atm_pathway | ATM pathway |
| pid | atr_pathway | ATR signaling pathway |
| pid | fanconi_pathway | Fanconi anemia pathway |
| biocarta | atrbrcapathway | role of brca1 brca2 and atr in cancer susceptibility |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD17
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