RAET1L


Summary: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
retinoic acid early transcript 1LMIM:611047Ensembl:ENSG00000155918HGNC:HGNC:16798PA1349186656q25.1

GO terms in RAET1L


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0046703natural killer cell lectin-like receptor binding
CCTASGO:0005576extracellular region
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0031225anchored component of membrane
BPIBAGO:0001913T cell mediated cytotoxicity
BPIBAGO:0006955immune response
BPIEAGO:0016032viral process
BPIBAGO:0030101natural killer cell activation
BPIBAGO:0042267natural killer cell mediated cytotoxicity
BPIBAGO:0042271susceptibility to natural killer cell mediated cytotoxicity

Gene expression in normal tissue: RAET1L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAET1L


DatabasePathway IDPathway Des.
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAET1L

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