RAMP2
Summary: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| receptor activity modifying protein 2 | MIM:605154 | Ensembl:ENSG00000131477 | HGNC:HGNC:9844 | PA34203 | 17q21.2 |
GO terms in RAMP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001605 | adrenomedullin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008565 | protein transporter activity |
| MF | IDA | GO:0008565 | protein transporter activity |
| MF | IBA | GO:0015026 | coreceptor activity |
| MF | ISS | GO:0015026 | coreceptor activity |
| MF | IGI | GO:0097643 | amylin receptor activity |
| MF | IPI | GO:1990409 | adrenomedullin binding |
| BP | IBA | GO:0001525 | angiogenesis |
| BP | IDA | GO:0001525 | angiogenesis |
| BP | IMP | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | ISS | GO:0002040 | sprouting angiogenesis |
| BP | IBA | GO:0006816 | calcium ion transport |
| BP | IDA | GO:0006816 | calcium ion transport |
| BP | IEA | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IPI | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0007507 | heart development |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | ISS | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0015031 | protein transport |
| BP | IDA | GO:0015031 | protein transport |
| BP | IBA | GO:0031623 | receptor internalization |
| BP | IDA | GO:0031623 | receptor internalization |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | IEA | GO:0032870 | cellular response to hormone stimulus |
| BP | IDA | GO:0034333 | adherens junction assembly |
| BP | ISS | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IDA | GO:0043116 | negative regulation of vascular permeability |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0070830 | bicellular tight junction assembly |
| BP | ISS | GO:0070831 | basement membrane assembly |
| BP | IBA | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0097084 | vascular smooth muscle cell development |
| BP | IGI | GO:0097647 | amylin receptor signaling pathway |
| BP | IPI | GO:1990410 | adrenomedullin receptor signaling pathway |
| BP | IDA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| BP | IEA | GO:2001214 | positive regulation of vasculogenesis |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005764 | lysosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005905 | clathrin-coated pit |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IDA | GO:1903143 | adrenomedullin receptor complex |
| CC | IDA | GO:1903440 | amylin receptor complex |
Gene expression in normal tissue: RAMP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAMP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-419812 | Calcitonin-like ligand receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAMP2
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