RAP1GAP
Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAP1 GTPase activating protein | MIM:600278 | Ensembl:ENSG00000076864 | HGNC:HGNC:9858 | PA34220 | 1p36.12 |
GO terms in RAP1GAP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016020 | membrane |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IDA | GO:0043087 | regulation of GTPase activity |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IMP | GO:1903697 | negative regulation of microvillus assembly |
| MF | NAS | GO:0003924 | GTPase activity |
| MF | EXP | GO:0005096 | GTPase activator activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017016 | Ras GTPase binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: RAP1GAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAP1GAP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392517 | Rap1 signalling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-8853659 | RET signaling |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAP1GAP
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