REEP1


Summary: This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
receptor accessory protein 1MIM:609139Ensembl:ENSG00000068615HGNC:HGNC:25786PA1349066802p11.2

GO terms in REEP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0032386regulation of intracellular transport
BPIDAGO:0051205protein insertion into membrane
BPIMPGO:0071786endoplasmic reticulum tubular network organization
CCIDAGO:0005737cytoplasm
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031966mitochondrial membrane
CCISSGO:0071782endoplasmic reticulum tubular network
MFIPIGO:0005515protein binding
MFIDAGO:0008017microtubule binding
MFIMPGO:0031849olfactory receptor binding

Gene expression in normal tissue: REEP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in REEP1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381753Olfactory Signaling Pathway
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1
iGMDRD353PD03259012
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in REEP1

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